A direct procedure for the micro-scale preparation of acyl derivatives of nucleophilic drugs from carboxylic acids for gc separation and identification.

W J Serfontein, L S de Villiers
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Abstract

Free carboxylic acids were converted into mixed anhydrides suitable for the acylation of nucleophilic drugs in a one-step procedure. By preparing more than one acyl derivative and comparing the retention times of the derivatives with those of authentic drug samples with reference to suitable internal standards, the positive identification of unknown drugs was possible. The method is suitable for use in conjunction with the microphase extraction of drugs.

以羧酸为原料制备亲核药物的酰基衍生物,用于气相色谱分离和鉴定。
游离羧酸在一步过程中转化为适合于亲核药物酰化的混合酸酐。通过制备一种以上的酰基衍生物,并参照合适的内标,将衍生物的保留时间与原药样品的保留时间进行比较,可以对未知药物进行阳性鉴定。该方法适用于药物的微相萃取。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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