Effect of physostigmine on Y-maze discrimination retention in the rat.

M D Stanes, C P Brown
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引用次数: 2

Abstract

A series of experiments was designed to assess the effect of physostigmine on the retention of an appetitively-reinforced Y-maze discrimination. The results supported in part the model of cholinergic involvement in long-term memory as proposed by Deutsch, in that physostigmine respectively impaired and enhanced well-remembered and poorly-remembered responses. However a modification of the model was presented to accommodate futher findings that variations in both dose-level of administered physostigmine and initial leraning ability influenced subsequent retention, depending on the training-testing interval.

芥子碱对大鼠y型迷宫辨别能力的影响。
我们设计了一系列的实验来评估毒豆碱对食欲增强的y迷宫辨别的保留的影响。结果在一定程度上支持了Deutsch提出的长期记忆中胆碱能参与的模型,即毒豆碱分别损害和增强了记忆良好和记忆不良的反应。然而,对模型进行了修改,以适应进一步的发现,即根据训练-测试间隔,给予的毒豆碱剂量水平和初始学习能力的变化都会影响随后的保留。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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