Gender-Specific Effects of Health and Lifestyle Markers on Individual BrainAGE

Abstract

This study quantifies the effects of health and lifestyle markers on individual brain aging in dementia-free elderly subjects, revealed by a relevance vector regression approach. In males, markers of metabolic syndrome as well as alcohol abuse were significantly related to increased Brain AGE scores of up to 9 years. In females, markers of healthy liver and kidney functions and an adequate supply of nutrients were significantly related to decreased Brain AGE scores.