An Approach to Assess ACh and NE Secretion inside Heart’s Myocardial Cell during R-peak Formation

Abstract

Human heart is one of the most complex structures of human body deals with unique and indispensable functionality to keep humans alive. Judgment of heart’s efficacy often relies on to what extent sympatho-vagal balance prevails and keeps the heart beating. This work deals with a two-approach-based solution to assess the secretion of acetylcholine (ACh) and norepinephrine (NE) inside heart’s myocardial cell during R-peak formation. Approach-I deals with formation of ECG peak, generation of action potential, and details of ACh and NE secretion inside myocardial cell. Approach-II analyzes and processes obtained cardiac signals in order to find out features necessary to define cardiac condition. Their combined analysis ends up refuting the assessing process with Respiratory sinus arrhythmia (RSA), Cardiac autonomic balance (CAB), and Cardiac autonomic regulation (CAR) in the range respectively of 0.04±0.025, −15.96±1.38, and 16.08±1.37 for NE predominance and 0.086±0.015, −14.63±0.333, and 14.76±0.33 for ACh predominance inside heart’s myocardial cell.