The role of calcium in the mechanisms of pathogenesis and pharmacotherapy of mental disorders: a brief review

Abstract

It is widely accepted that mental disorders cause significant damage to human health. The mechanisms of their pathogenesis have not yet been fully clarified. Hereditary, environmental, metabolic, and other factors are important in these mechanisms. Calcium is considered a possible participant in the mechanisms of pathogenesis. Its serum level is controlled by hormonal regulation. Thyroid and other disorders lead to calcium levels disturbances (hypocalcemia and hypercalcemia). Various physical and mental symptoms accompany these conditions. To clarify the pathogenetic mechanisms of mental disorders and to develop new drug interventions, it is essential to clarify the role of various participants in them, including calcium. The medications that regulate the calcium level, particularly calcium channel blockers, can help develop new treatment methods for mental disorders. It is necessary to study the mentioned drugs’ mechanisms of action on mental disorders and the possible ways of their improvement and practical application.