Persistence of relapse of morphine-seeking behavior in rats: the relative role of certain biological variables.

A S Schwartz, P L Marchok
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引用次数: 1

Abstract

The theory that narcotic-induced protracted biological changes are responsible for relapse of opiate-reinforced behavior was examined in the rat. Groups of rats were conditioned to prefer a distinctive environment by pairing it with morphine doses from 1-200 mg/kg, and were retested for persistence of this preference after a 3-week abstinence period. They were then observed for protracted signs such as sensitivity to naloxone, tolerance to morphine analgesia, hyperaggression, or changes in endocrine activity. Acquisition and relapse of the preference, as well as long-term tolerance, were dose related. None of the purported protracted signs showed any consistent relationship to the tendency to relapse. However, relapse correlated significantly with original acquisition scores in all relapsing groups. The results suggest that original conditioning factors, rather than protracted changes, are responsible for the observed relapse.

大鼠吗啡寻求行为复发的持久性:某些生物学变量的相对作用。
理论,麻醉诱导的持久的生物学变化是负责复发的阿片强化行为的大鼠进行了检验。各组大鼠通过吗啡剂量从1-200 mg/kg配对来适应不同的环境,并在3周的戒断期后重新测试这种偏好的持久性。然后观察他们的长期体征,如对纳洛酮的敏感性,对吗啡镇痛的耐受性,过度攻击或内分泌活动的变化。偏好的获得和复发以及长期耐受性与剂量有关。这些所谓的长期症状都没有显示出与复发倾向有任何一致的关系。然而,在所有复发组中,复发与原始习得得分显著相关。结果表明,原来的条件因素,而不是长期的变化,是负责观察到的复发。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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