Blood flow model for noninvasive diagnostics

2011 IEEE GCC Conference and Exhibition (GCC) Pub Date : 2011-04-19 DOI:10.1109/IEEEGCC.2011.5752521

D. Fricke, H. Koroll, J. Kraitl, H. Ewald

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引用次数: 8

Abstract

An artificial blood flow model (BFM) based on the human circulatory system was developed to allow a controlled variation of the blood parameter as total haemoglobin concentration (ctHb), oxyhaemoglobin (O2Hb) and carboxyhaemoglobin (COHb). For this reason the optical properties of the blood were observed by online spectrometer measurements. The purpose was to observe the absorption, transmission and scattering properties of human whole blood in a wavelength range from 400 to 1700 nm. All the noninvasive measurements of the whole blood transmission-spectra were compared with sample results obtained by a Blood Gas Analyzer (BGA) to validate the results. For all measurements donor erythrocyte concentrates were used. The concentration of haemoglobin was changed by adding fixed amounts of blood plasma to the erythrocyte concentrate. Blood circulation and predetermined oxygen state were adjusted with an extra-corporal circulation unit. The blood was gently stirred and kept flowing through the blood tubes and the specially designed cuvettes (for spectrometric measurements). Oxygen saturation and COHb were adjusted by a continuous flow of N2, N2-CO- and N2-O2-mixture through a hollow fiber membrane oxygenator. The blood temperature was kept constant at 37 °C via a tube heating mechanism and a separate water circulation through the Oxygenator. In the future the blood flow model can be used for testing newly developed optical prototype devices

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无创诊断的血流模型

建立了基于人体循环系统的人工血流模型(BFM)，以控制总血红蛋白浓度(ctHb)、氧合血红蛋白(O2Hb)和羧化血红蛋白(COHb)等血液参数的变化。因此，血液的光学特性是通过在线光谱仪测量来观察的。目的是观察人体全血在400 ~ 1700 nm波长范围内的吸收、透射和散射特性。将全血透射光谱的所有无创测量结果与血气分析仪(BGA)获得的样品结果进行比较，以验证结果。所有测量均使用供体红细胞浓缩物。血红蛋白的浓度是通过向红细胞浓缩物中加入一定量的血浆而改变的。血液循环和预定的氧状态调整与一个额外的身体循环单位。血液被轻轻搅拌，并不断流过血液管和专门设计的试管(用于光谱测量)。通过中空纤维膜充氧器连续流动N2、N2- co -和N2- o2混合物来调节氧饱和度和COHb。通过管式加热机制和单独的水循环通过氧合器将血液温度保持在37°C。在未来，血流模型可用于测试新开发的光学原型装置

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

2011 IEEE GCC Conference and Exhibition (GCC)

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