The Effect of Salbutamol Nebul Treatment on Systolic Pulmonary Artery Pressure in Newly Diagnosed Patients with Chronic Obstructive Pulmoner Disease

Abstract

COPD may not only be a functional disorder of the lungs, but may also have systemic effects [1]. Extrapulmonary findings are described in skeletal muscle, bone and cardiovascular system [2]. It is thought that low-intensity chronic inflammation may cause oxidative stress and endothelial dysfunction, thus leading to ischemic heart disease or stroke [3,4]. The occurrence of pulmonary HT in patients with COPD usually indicates progression of the disease and poor prognosis. Pulmonary arterial hypertension [PAH] is diagnosed when mean pulmonary arterial pressure exceeds 25 mm-Hg at rest or 30 mm-Hg during exercise. Right heart catheterization is the gold standard method for measuring pulmonary artery pressure. In addition, echocardiography can be used for this purpose [5]. PAH is present in approximately 50% of patients with COPD, varying according to diagnostic methods [6-9]. The pulmonary artery pressure may increase significantly during exercise, which may lead to an erroneous assessment of exercise capacity. It has been determined that pulmonary artery pressure increases with age in healthy people. However, an increase in pressure in patients with COPD may result in a higher load in the heart and circulation, and reduced exercise tolerance [10-12]. The development of PHT in patients with COPD is an important influence that may transform the disease into pulmonary heart disease [13]. The pathogenesis of PHT in COPD has not yet been clearly elucidated, but it is thought that oxidative stress plays a role [14-18]. Although the negative effect of physical exercise on pulmonary artery pressure in patients with newly diagnosed and untreated COPD is known, its effect on the prognosis of the disease is still unclear [19-22]. The aim of this study is to investigate the effect bronchodilator treatment on systolic pulmonary artery pressure induced by exertion test in patients with COPD. Backround The Effect of Salbutamol Nebul Treatment on Systolic Pulmonary Artery Pressure in Newly Diagnosed Patients with Chronic Obstructive Pulmoner Disease