Microfluidic Circulating Tumour Cell Sorter Using Deterministic Lateral Displacement

Abstract

This paper presents the separation of rare circulating tumour cells (CTCs) in the range of $15-30\mu \text{m}$ by designing the novel microfluidic channel to prognose the level of cancer. Prognosing the level of CTCs in a patient's blood sample will greatly reduce the mortality rate. The developed microchannel structure utilizes the concept of deterministic lateral lateral displacement. Inclusion of arrays of triangular posts with critical diameter of $42\mu \text{m}$ improves the separation efficiency. The optimistic microchannel’s efficiency is analyzed by validating critical diameter. Further particle tracing is employed and improved the device throughput.