HER2/CEN17 biomarkers detection in CISH images

Abstract

The article presents an algorithm of HER2/CEN17 genes biomarkers detection in CISH images (Chromogenic in situ hybridization) which supports the diagnosis of the breast cancer. The algorithm is based on morphological transformations, the usage of structural elements (strel objects) and application of distance function. The developed transformation increases the contrast between biomarkers and background which makes possible the use of simple threshold methods for final detection of biomarkers.