[Oxidative phosphorylation in rat heart mitochondria under administration of hydrocortisone and insulin].

Ukrains'kyi biokhimichnyi zhurnal Pub Date : 1977-09-01
D A Sutkovyj, A M Alferov
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Abstract

The rate of oxidative phosphorylation was studied in heart mitochondria of rats which were administered hydrocortisone and then corticoid in combination with insulin. It is established that 5 h after a single administration of hydrocortisone oxidative phosphorylation increases slightly and is statistically insignificant. Injections of corticosteroids to animals for 14 days inhibit considerably the rate of oxidation and phosphorylation, cause a decrease in the values of respiratory control and APD/O coefficient. Administration of insulin simultaneously with hydrocortisone to animals normalizes these disturbances to a considerable extent.

氢化可的松和胰岛素对大鼠心脏线粒体氧化磷酸化的影响。
研究了氢化可的松和皮质激素联合胰岛素对大鼠心脏线粒体氧化磷酸化的影响。结果表明,氢化可的松单次给药后5小时,氧化磷酸化水平略有升高,但无统计学意义。给动物注射皮质类固醇14天后,氧化和磷酸化速率明显受到抑制,呼吸控制值和APD/O系数下降。同时给动物注射胰岛素和氢化可的松在很大程度上使这些紊乱恢复正常。
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