Reflectance Confocal Microscopy in the Diagnosis of Non- Melanoma Skin Cancer and Benign Lesions Versus Normal Skin: A Blinded Prospective Trial

Abstract

1. Reflectance Confocal Microscopy (RCM) generates images comparable to histology. Past clinical trials on NMSC using RCM have shown promising results 2 3 4 , but the role of RCM needs better definition. Objectives We aimed to compare RCM to excision biopsy histology in NMSC management in an Australian population to evaluate its diagnostic use.Materials and methodsPatients referred with difficult-to-diagnose skin lesions before excision were included. RCM images of each lesion were obtained prior to surgical intervention and were compared with the post-operative histological findings. Results A total of 137 patients were