MODERN DIAGNOSIS OF PLACENTAL DYSFUNCTION AND ITS COMPLICATIONS

V. Lazurenko, I. Borzenko, O. Lyashchenko, O. B. Ovcharenko, D. Tertyshnyk
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引用次数: 1

Abstract

The aim of the study was to improve the modern diagnosis of placental dysfunction and its complications. Materials and methods. The study involved a prospective survey of 70 pregnant women divided into the main group (pregnant women with placental dysfunction) (n = 50) and the control group (n = 20). The main group was divided into subgroups of pregnant women with placental dysfunction and fetal growth retardation (n = 30) and pregnant women with placental dysfunction without fetal growth retardation (n = 20). The control group comprised 20 pregnant women with physiological gestation. Apart from history taking, the study comprised obstetric and general clinical examination, evaluation of endothelium- dependent vasodilation, serum concentrations of soluble forms of vascular and platelet- endothelial molecules of cell adhesion 1, indicators of athrombogenicity of the vascular growth wall, uterine-placental-fetal blood circulation, pathomorphological and histometric examination of the placenta. Results. Based on the obtained clinical-morphological and endotheliotropic criteria, a personalized clinical algorithm for managing pregnant women with placental dysfunction was developed and implemented. Conclusions. Assessment of pregnancy results in a prospective clinical study showed that the proposed algorithm for personalization of the risk of perinatal abnormalities not only helped to avoid antenatal mortality, but also to prevent intranatal and early neonatal losses in patients with placental dysfunction and fetal growth retardation.
胎盘功能障碍及其并发症的现代诊断
本研究的目的是提高胎盘功能障碍及其并发症的现代诊断。材料和方法。本研究对70名孕妇进行前瞻性调查,分为主组(有胎盘功能障碍的孕妇)50例和对照组(20例)。主组分为胎盘功能障碍合并胎儿生长迟缓孕妇(n = 30)和胎盘功能障碍无胎儿生长迟缓孕妇(n = 20)两组。对照组为生理妊娠的孕妇20例。除病史记录外,该研究还包括产科和一般临床检查、内皮依赖性血管舒张的评估、血管和血小板内皮细胞粘附分子可溶性形式的血清浓度、血管生长壁的血栓形成指标、子宫-胎盘-胎儿血液循环、胎盘的病理形态学和组织计量学检查。基于获得的临床形态学和促内皮标准,开发并实施了一种个性化的临床算法来管理胎盘功能障碍孕妇。一项前瞻性临床研究对妊娠结果的评估表明,所提出的围产期异常风险个性化算法不仅有助于避免产前死亡,还有助于预防胎盘功能障碍和胎儿生长迟缓患者的产前和早期新生儿损失。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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