Cell regeneration medicine in case of salih myopathy and hypoxic encephalopathyhy

Abstract

(GW) have low immunogenicity due to the fact that they do not activate the proliferation of T cells, as they do not express the main histocompatibility complex class II (MHCII) or the cd40, cd80 and cd86 molecules, necessary for the activation of t cells.3 The world literature has not shown that when CMMGW is administered, the proliferation of lymphocytes is suppressed and also does not activate mhc20. For this reason, rejection after cell graft transplantation is minimal or null, even among individuals without any consanguinity.4 Another beneficial effect is that MSCs have an immunomodulatory effect on T and B lymphocytes, dendritic cells and NK cells, since it can inhibit the proliferation of immune cells and reduce the secretion of cytokines and the presence of the subtypes of cells infiltrated in tissue.3,5–8 which attenuates inflammation and promotes wound healing. These characteristics and properties of allogeneic CMMGW provide an advantage for tissue regeneration and thus achieve wound closure and avoid rejection.9–12