Evaluation of the Effect of Topically Applied Probiotics on Interleukin-10 and Osteoprotegerin as an Adjunctive Treatment of Stage І and П Grade A Periodontitis Cases

Abstract

Aim: the use of probiotic gel may be considered as beneficial treatment for periodontitis. This study was directed to evaluate the possible effect of topically applied probiotics on Interleukin-10 (IL-10) and osteoprotegerin (OPG) combined with scaling and root planning (SRP) in treatment of stage І and П grade A periodontitis. Subjects and Methods: 18 female patients were divided randomly into two equal groups. Group I (PG): received SRP combined with topically applied probiotics gel. Group II(CG): received SRP only. All patients were received phase I periodontal therapy. Then all patients were evaluated clinically and biochemically at base line, one month and three months after periodontal therapy Results recorded, tabulated and statistically analyzed using SPSS (statistical package for social sciences). Results: Clinical parameters such as plaque index (PI), gingival index (GI), probing pocket depth (PPD) and clinical attachment level (CAL) were evaluated. In all groups there was a significant reduction regarding the clinical parameters. There was insignificant better results regarding PI and GI in group I. while, there was significant better results regarding PPD and CAL in group I than group II. OPG levels showed insignificant better results in PG than CG but IL-10 levels showed significant better results in PG over time than CG. Conclusion: Adjunctive topically applied probiotic gel exhibited anti inflammatory effect through the significant expression of IL-10 after treatment of stage I and II grade A periodontitis patients. On the other hand seemed to be non significantly improve the bone formation through the limited expression of OPG