Ecological investigations on arsenic dietary intake and endemic chronic poisoning in man: dose-response curve.

Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe B: Hygiene, praventive Medizin Pub Date : 1977-08-01

R Zaldívar

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Abstract

The city of Antofagasta (northern Chile), is an area of endemic chronic arsenic poisoning due to arsenic-polluted drinking water. In order to explore the possibility of a dose-response relationship, a dietary survey was carried out in 1972 in that city for measuring the daily fluid intake in the various age groups. The sample (N = 220) included 13 males and 13 females in each age group, except the 81-90 year-old group with 6 males and 6 females. A linear relationship was found between arsenic dose (mg/kg body weight/day) and age for males being P less than 0.001 (slope) and r = -0.6712; and for females P less than 0.001 (slope) and r = 0.6667. Age-specific prevalence rates per 100,000 population (both sexes combined) for chronic arsenic poisoning in Antofagasta Commune for the 1968-71 period, were plotted against mean arsenic doses (mg/kg body weight/day) by age group. A dose-response curve was computed, being F = 83.19, d.f. = 1,7 and P less than 0.01 (slope). The correlation coefficient was + 0.9604.

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人砷膳食摄入与地方性慢性中毒的生态学调查:剂量-反应曲线。

安托法加斯塔市(智利北部)是一个地方性慢性砷中毒地区，由于砷污染的饮用水。为了探索剂量-反应关系的可能性，1972年在该市进行了一项饮食调查，以测量不同年龄组的每日液体摄入量。样本(N = 220)，除81-90岁年龄组男6女6外，每个年龄组男13女13。男性砷剂量(mg/kg体重/天)与年龄呈线性关系，P < 0.001(斜率)，r = -0.6712;女性P < 0.001(斜率)，r = 0.6667。1968年至1971年期间，安托法加斯塔公社每10万人(男女加起来)慢性砷中毒的特定年龄流行率与按年龄组划分的平均砷剂量(毫克/公斤体重/天)作了对比。计算出剂量-反应曲线，F = 83.19, d.f = 1,7, P < 0.01(斜率)。相关系数为+ 0.9604。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe B: Hygiene, praventive Medizin

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