Health management using probiotics

Abstract

developing high cholesterol [19-23]. Several mechanisms had been postulated regarding the effects of hypocholesterolemic induced by lactic acid bacteria. Assimilation of cholesterol through cell growth or attachment to the cell surface was one of the mechanisms carried by lactic acid bacteria [24,25]. The second method involves the bile salts deconjugation due to the enzyme bile salt hydrolase (BSH), which hydrolyzes conjugated bile salts of taurine and glycine into residues of amino acid and free bile salts (bile acids). As a result of being less soluble, these deconjugated bile salts were expelled in the feces and replenished by fresh bile salts, which the body produced from cholesterol. The body removes more cholesterol when more bile salts are secreted [16,26]. When cultivated in broth medium supplemented with 0.2% bile salts, studies showed that Lactobacillus acidophilus PI06 appeared to have an active bile salt hydrolase that eliminated cholesterol from the body roughly 29.02% to 45.3%. [27,28] (Figure 1).