THE ROLE OF PRO- AND ANTI-INFLAMMATORY CYTOKINES IN THE DEVELOPMENT AND COURSE OF ABDOMINAL SEPSIS

Abstract

Summary. The proposed work: To improve the results of surgical treatment of patients with abdominal sepsis by studying the different course of AS depending on the synthesis, balance of pro- and anti-inflammatory cytokines, which are produced by MNK cells of the peripheral blood of patients with AS under the action of ligands of TLR receptors in the dynamics of the disease with an assessment of their prognostic significance. The results. An analysis of the treatment of 38 patients with abdominal sepsis, who were evaluated for the synthesis of pro- and anti-inflammatory cytokines in the postoperative period, depending on the presence or absence of complications, is given. The conducted research allowed us to formulate a new diagnostic criterion, with the help of which it is possible to predict its further course in the early stages of the development of AS with the allocation of gradations of the probability of the development of complications Conclusions: 1. Studying the profile of pro- and anti-inflammatory cytokines, spontaneously and under the influence of TLR ligands, made it possible to distinguish 2 subgroups among the examined patients: favorable and unfavorable. 2. In patients with a favorable course of the disease, the balance of inflammatory cytokines increased due to IL-8, and in patients with an unfavorable course - IL-6, which can serve as a prognostic criterion of the course and consequences of AS.