Influence of donor complement component allotype on renal transplantation outcome

Abstract

Background Improvements in clinical care and immunosuppressive medications have provided positive outcomes following kidney transplantation such as reducing acute rejection rates. Activation of the complement cascade is inevitable in kidney transplantation because of both the specific and nonspecific immunologic responses of the recipient. This study provides insights on the influence of the donor C3 allotype on renal transplant outcome (graft function). Patients and methods The present study was conducted on 50 pairs of donors and recipients of renal transplantation who fulfilled the inclusion and exclusion criteria. C3 allotypes of donor–recipient pairs were determined and divided into four genotypic groups according to the C3F allotype of the donor and the recipient. The four genotypic groups were analyzed for association with graft function and assessed by serum creatinine, blood urea, and glomerular filtration rate. Results There was a positive statistically significant difference for the group FF/FS donor into SS recipient in comparison with other genotype groups of C3 among recipients, as shown by improvement in glomerular filtration rate, serum creatinine, and blood urea. Conclusion The presence of C3 (F) allele either homozygous or heterozygous in the donor and the absence of this allele in the recipient give a better renal allograft function.