Prospective

Écoréfugiés au pays des bayous. Les Indiens houmas face au golfe du Mexique Pub Date : 2020-05-21 DOI:10.2307/j.ctt6wrbt1.4

PhD Shannon Morgan-Pelosi, Xingping Zhao, Jiezhi Ma, Livia Xhindoli, Gabriella Schivardi, Luigi Antonio De Vitis, Benedetto Emmanuel, Guillot Giulia, Maria Teresa Pappalettera, Alessia Achilarre, Simone Aloisi, Annalisa Bruni, Garbi Giovanni, Vanna Damiano Aletti, Angelo Zanagnolo, Nicoletta Maggioni, Colombo Ilaria, Francesco Multinu Betella

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引用次数: 279

Abstract

. Clinical information and trans-vaginal ultrasound measurements were also obtained. Univariate logistic regression and receiver operating characteristic curve analysis were performed to assess the risk factors and diagnostic efficacy of DNA methylation detection. Results Age, body mass index (BMI) (cid:1) 25 kg/m 2 , endometrial thickness (cid:1) 11 mm, CDO1 D Ct £ 8.4, CELF4 D Ct £ 8.8, and combined gene methylation showed significant associations with endometrial cancer in young women (p < 0.05). The highest diagnostic accuracy (AUC = 0.90) for endometrial cancer was achieved with CDO1/CELF4 methylation testing. Sensitivity and specificity were 91.7% and 88.8%, respectively. Combining transvaginal ultrasound with DNA methylation testing improved sensitivity to 95.8% but decreased specificity to 68.0%. Conclusion DNA methylation detection in cervical cells provides enhanced accuracy for endometrial cancer diagnosis in reproductive-aged women with AUB. The combination of CDO1 and CELF4 methylation testing with transvaginal ultrasound improves sensitivity, highlighting its potential as a valuable screening approach.

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．临床资料和经阴道超声测量也得到。采用单因素logistic回归和受试者工作特征曲线分析评估DNA甲基化检测的危险因素和诊断效果。结果年龄、体重指数(BMI) (cid:1) 25 kg/ m2、子宫内膜厚度(cid:1) 11 mm、CDO1 D Ct£8.4、CELF4 D Ct£8.8、联合基因甲基化与年轻女性子宫内膜癌有显著相关性(p < 0.05)。CDO1/CELF4甲基化检测对子宫内膜癌的诊断准确率最高(AUC = 0.90)。敏感性为91.7%，特异性为88.8%。经阴道超声联合DNA甲基化检测提高了95.8%的敏感性，但降低了68.0%的特异性。结论宫颈细胞DNA甲基化检测可提高育龄期AUB妇女子宫内膜癌诊断的准确性。经阴道超声联合CDO1和CELF4甲基化检测提高了敏感性，突出了其作为一种有价值的筛查方法的潜力。

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Écoréfugiés au pays des bayous. Les Indiens houmas face au golfe du Mexique

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