SCREENING OF GROUP B STREPTOCOCCUS AGALACTIAE AMONG PREGNANT WOMEN IN DUHOK CITY/ KURDISTAN REGION/ IRAQ

Diyar MOHAMMED TAHER ALI, Abdulrahman TOWFEEQ SAADI
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Abstract

Background: Pregnant women colonized with Streptococcus agalactiae-Group B Streptococci (GBS) can transmit the bacteria to their new-borns at the time of birth. Intrapartum antibiotic prophylaxis (IAP) can prevent this transmission. The aim of this study is to find out the carriage rate of group B streptococci isolated from pregnant women in Duhok city, Iraq. Other aim is to study the Antibiotic susceptibility patterns of the isolates and to detect the risk factors associated with the growth of these bacteria. Methods: Exactly 821 pregnant women living in Duhok city were randomly screened for GBS colonization, over a period of 7 months from 1st of January, 2022 till 1st of August, 2022. High vaginal swabs (HVS) sample were collected, processed and identification was performed by Vitek system 2. The isolated strains of GBS were selected for in vitro susceptibility testing. As well as also risk factors associated with infection were assessed. Results: GBS was detected in 37/821 accounted (4.51%) pregnant women. Risk factors such as vaginal discharge, UTI, Diabetes, abortions and still birth did not show major differences between positive and negative cases of GBS. Pencillin G, Co-Amoxiclav, Nitrofurantoin, Vancomycin and Ampiciilin have shown the highest sensitivity percentages (93.9%, 93.8%, 88.9%, 87.5% and 84% respectively). The sensitivity rate for other B-Lactams: Cepholothin, Ceftriaxone and Cefixim were: 70.6%, 63% and 78% respectively. The sensitivity for Gentamicin was 38.9% and 48.4% for Ciprofloxacin. However, the lowest sensitivity rates were detected for Clindamycin, Amikacin and Erythromycin: 26.1%, 30% and 30.5% respectively. Conclusions: Carriage rates of GBS among pregnant women in this setting are still low-grade. Penicillin and Ampicillin are the drugs of choice (intra-partum prophylaxis) against GBS in pregnancy. Co-amoxiclave and Vancomycin also had a high level of sensitivity.
杜胡克市/库尔德斯坦地区/伊拉克孕妇无乳b群链球菌筛查
背景:感染无乳链球菌- B群链球菌(GBS)的孕妇可在分娩时将细菌传播给新生儿。产时抗生素预防(IAP)可预防这种传播。本研究的目的是了解从伊拉克杜霍克市孕妇分离的B族链球菌的携带率。另一个目的是研究分离物的抗生素敏感性模式,并检测与这些细菌生长有关的危险因素。方法:从2022年1月1日至2022年8月1日,在杜霍克市随机筛选821名孕妇进行GBS定植。采集高阴道拭子(HVS)样本,使用Vitek系统2进行处理和鉴定。选择分离的GBS菌株进行体外药敏试验。同时也评估了与感染相关的风险因素。结果:37/821(4.51%)孕妇检出GBS。阴道分泌物、尿路感染、糖尿病、流产和死产等危险因素在GBS阳性和阴性病例之间没有显着差异。青霉素G、Co-Amoxiclav、呋喃妥因、万古霉素和氨苄西林的敏感性最高,分别为93.9%、93.8%、88.9%、87.5%和84%。其他b -内酰胺类药物头孢肽、头孢曲松和头孢昔平的敏感性分别为70.6%、63%和78%。庆大霉素和环丙沙星的敏感性分别为38.9%和48.4%。而克林霉素、阿米卡星和红霉素的敏感性最低,分别为26.1%、30%和30.5%。结论:该地区孕妇的GBS携带率仍然很低。青霉素和氨苄青霉素是预防妊娠期GBS的首选药物(产内预防)。复方阿莫昔拉韦和万古霉素也具有较高的敏感性。
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