Transduction of human MCP‐3 by a parvoviral vector induces leukocyte infiltration and reduces growth of human cervical carcinoma cell xenografts

Abstract

The oncosuppressive properties of some autonomous parvoviruses such as H‐1 virus, together with their low pathogenicity, make them attractive vectors for tumor‐directed gene therapy. Indeed, it was recently shown that these viruses became endowed with an enhanced oncosuppressive activity after they had been engineered to deliver a recognized therapeutic transgene. This prompted us to use a parvoviral vector to analyse the antineoplastic capacity of MCP‐3 (monocyte chemotactic protein‐3), a CC chemokine which has a broad spectrum of target cells, and can thus be considered to be a promising candidate for cancer treatment.