Neutralization of crotoxin and crude venom by rabbit antiserum to crotalus phospholipase A

Mitsuko A. Hanashiro, Maria Helena Da Silva , Otto G. Bier
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引用次数: 12

Abstract

Rabbits were immunized with purified phospholipase A isolated by ion exchange chromatography from the venom ofCrotalus durissus terrificus, a South American rattlesnake. As shown byin vitro andin vivo tests, the antiserum was able to neutralize the hemolytic and toxic activities of the purified enzyme, as well as of crotoxin and the crude venom.

兔抗鼠尾草磷脂酶A血清中和鼠尾草毒素和粗毒液的研究
用离子交换色谱法从南美响尾蛇crotalus durissus terrificus毒液中分离纯化的磷脂酶A免疫家兔。体外和体内试验表明,抗血清能够中和纯化酶的溶血和毒性活性,以及响尾蛇毒素和粗毒液。
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