Adrenalectomy attenuates electroconvulsive shock-induced retrograde amnesia in rats

Abstract

The involvement of the adrenal glands in the induction of electroconvulsive-shock amnesia was examined. Sham-adrenalectomized rats given an electroconvulsive shock immediately following a single passive avoidance acquisition trial showed amnesia when tested 24 hr after training. Bilateral adrenalectomy 10 days before training protected rats against the disruptive effects of electroconvulsive shock on passive avoidance behavior.