{"title":"Effect of handling-induced seizures on passive avoidance learning in the Mongolian gerbil (Meriones unguiculatus)","authors":"Amy Rothman Schonfeld, Stanley D. Glick","doi":"10.1016/S0091-6773(78)92971-1","DOIUrl":null,"url":null,"abstract":"<div><p>The effect of handling-induced seizures on passive avoidance behavior was investigated in the gerbil. In the first experiment, ictal activity immediately before Day 1 training significantly impaired retention on Day 2; after additional training on Day 2, retention was normal on Day 3. In the second experiment, a 24-hr interval was allowed between seizure testing and passive avoidance training. No difference between seizing and nonseizing groups was seen during the Day 2 training or Day 3 retention trials. Therefore, the Day 2 impairment in the first experiment was attributed to the immediate effect of the seizure on Day 1 learning. It was suggested that the poor performance of some gerbils in passive avoidance may be attributed to pretraining ictal activity.</p></div>","PeriodicalId":75577,"journal":{"name":"Behavioral biology","volume":"24 1","pages":"Pages 101-106"},"PeriodicalIF":0.0000,"publicationDate":"1978-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0091-6773(78)92971-1","citationCount":"7","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Behavioral biology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0091677378929711","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 7
Abstract
The effect of handling-induced seizures on passive avoidance behavior was investigated in the gerbil. In the first experiment, ictal activity immediately before Day 1 training significantly impaired retention on Day 2; after additional training on Day 2, retention was normal on Day 3. In the second experiment, a 24-hr interval was allowed between seizure testing and passive avoidance training. No difference between seizing and nonseizing groups was seen during the Day 2 training or Day 3 retention trials. Therefore, the Day 2 impairment in the first experiment was attributed to the immediate effect of the seizure on Day 1 learning. It was suggested that the poor performance of some gerbils in passive avoidance may be attributed to pretraining ictal activity.
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