Effects of aldactazide and DOCA injections on saline preference in gerbils (Meriones unguiculatus)

Roderick Wong, Wayne Jones
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引用次数: 2

Abstract

Experiment 1 assessed the percentage of 4.0, 6.0, and 8.0% NaCl solution ingested by gerbils when they were given a choice between one of these saline solutions and water. The gerbils showed a uniformly low level of acceptance of these hypertonic solutions. When given a choice between 4.0 and 8.0% NaCl (Expt 2), the gerbils showed a preference for 4.0% saline. Experiment 3 evaluated the effects of Aldactazide on the gerbils' intake of 6.0% NaCl solution. The results indicated that relative to intake before and after the injection days, the gerbils showed a significant increase in saline intake. Experiment 4 examined the effects of DOCA injections on the gerbils' intake of 6.0% NaCl. The effects were dose-related. Injections of 5 mg of DOCA significantly increased the gerbils' saline intake while injections of 1 mg of the mineralocorticoid had no effect.

醛达他嗪和DOCA注射液对沙鼠生理盐水偏好的影响
实验1评估了沙鼠在这些盐水溶液和水之间做出选择时,摄入4.0、6.0和8.0% NaCl溶液的百分比。沙鼠对这些高渗溶液的接受程度一致较低。当给出4.0和8.0% NaCl(实验2)之间的选择时,沙鼠表现出对4.0%盐水的偏好。实验3评价Aldactazide对沙鼠摄入6.0% NaCl溶液的影响。结果表明,相对于注射前和注射后,沙鼠的生理盐水摄入量显著增加。实验4考察了注射DOCA对沙鼠6.0% NaCl摄取量的影响。这些影响与剂量有关。注射5mg的DOCA显著增加沙鼠的生理盐水摄入量,而注射1mg的矿化皮质激素则没有效果。
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