Treatment of chronic thromboembolism with Arvin, oral fibrinolytics and standard anticoagulants.

Abstract

In most Hospitals, the treatment of thromboembolic disease consists of heparin and simultaneous oral therapy instituted usually with Warfarin or phenidione; this oral therapy is continued for 3-12 months. However, in some patients, the thromboembolic disease progresses or recurs despite adequately controlled anticoagulant therapy. Chronic thromboembolic disease then is established and the recurrences of venous thrombosis and pulmonary embolism are frequent and disabling. In an attempt to prevent, reduce or treat chronic idiopathic thromboembolic disease, we have used Arvin in combination with heparin, phenformin, ethyloestrenol and warfarin in a new regime for 3-4 months. Defibrination