{"title":"Effect of roentgen, cyclotron neutron, or mixed neutron-photon fractionated irradiation of mice. LD50/4 day values.","authors":"J S Rasey, N J Nelson","doi":"10.3109/02841867709133974","DOIUrl":null,"url":null,"abstract":"<p><p>Mice were whole-body-irradiated with 5 fractions of roentgen rays in 5 days, 5 fractions of cyclotron neutrons in 5 days, or with mixed neutron-photon fractionated radiation, in the sequence n-n-x-x-x or n-x-x-x-n. The LD50/4 day values were determined. Roentgen rays and neutrons interact in the additive manner in the mixed fractionation schemes: effective dose per fraction is as predicted from the roentgen ray-only and neutron-only experiments. This essentially agrees with HENDRY et coll. (1976). However, no trend was found towards a less-than -additive effect which was observed by those authors and has also been suggested in skin response to mixed schemes (NELSON et coll. 1975).</p>","PeriodicalId":7139,"journal":{"name":"Acta radiologica: therapy, physics, biology","volume":"16 6","pages":"525-8"},"PeriodicalIF":0.0000,"publicationDate":"1977-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841867709133974","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta radiologica: therapy, physics, biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3109/02841867709133974","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
Mice were whole-body-irradiated with 5 fractions of roentgen rays in 5 days, 5 fractions of cyclotron neutrons in 5 days, or with mixed neutron-photon fractionated radiation, in the sequence n-n-x-x-x or n-x-x-x-n. The LD50/4 day values were determined. Roentgen rays and neutrons interact in the additive manner in the mixed fractionation schemes: effective dose per fraction is as predicted from the roentgen ray-only and neutron-only experiments. This essentially agrees with HENDRY et coll. (1976). However, no trend was found towards a less-than -additive effect which was observed by those authors and has also been suggested in skin response to mixed schemes (NELSON et coll. 1975).
以5天5次的x射线、5天5次的回旋中子、或以n-n-x-x或n-x-x-x-n的顺序对小鼠进行全身照射。测定LD50/4日值。在混合分馏方案中，伦射线和中子以加性方式相互作用:每组分的有效剂量与纯伦射线和纯中子实验预测的相同。这与HENDRY et coll的观点基本一致。(1976)。然而，没有发现这些作者观察到的小于加性效应的趋势，并且在皮肤对混合方案的反应中也提出了这种趋势(NELSON et coll)。1975)。
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