[Role of antigens and adjuvant substances in the histological response in experimental granulomas (immunogenic granuloma)].

Annales d'anatomie pathologique Pub Date : 1977-01-01
G Balouet, M Baret, E Relyveld, P Ravisse, J Levaditi
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Abstract

The injection in rabbits of vaccinal antigens combined with immunity adjuvants (in particular calcium phosphate) causes a local lesion in which it is possible to recognize histologically, after a transitory afflux of polymorphonuclear leukocytes, a central area of adjuvant deposit, a middle area of histiocytes and monocytes, and a peripheral immunogenic area of lymphocytes and plasmocytes. These two cellular zones are rich in highly fluorescent cells in the presence of an antiglobulin serum with an embedding technique which respects to the upmost the structures and immunoreactivity of the cells. These histological features are not completely observed on the separate injection of antigen or adjuvant. They must be interpreted, after a fleeting non-specific reaction, while taking into account the still poorly understood method of action of the inorganic adjuvant and spread of the antigen in the organism.

[抗原和佐剂在实验性肉芽肿(免疫原性肉芽肿)组织学反应中的作用]。
在兔体内注射疫苗抗原和免疫佐剂(特别是磷酸钙)会引起局部病变,在短暂的多形核白细胞流入后,可以在组织学上识别出中心区域的佐剂沉积,中间区域的组织细胞和单核细胞,以及淋巴细胞和浆细胞的周围免疫原区。这两个细胞区富含高荧光细胞,在抗球蛋白血清的存在下,采用包埋技术,最重要的是考虑到细胞的结构和免疫反应性。这些组织学特征在单独注射抗原或佐剂时不能完全观察到。它们必须在短暂的非特异性反应后进行解释,同时考虑到仍然知之甚少的无机佐剂的作用方法和抗原在生物体中的传播。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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