[Investigations on the antimicrobial activity of amin-aldehyde-condensates. 3. Communication: n,o-acetals (author's transl)].

Abstract

In the scope of our research about the antimicrobial activity of amin-aldehyde-condensates a number of partly new N,O-acetals was synthesized by reaction of formaldehyde with several alcohols and secondary amines. Structures and physically constants are shown in the tables 1 and 2. The antimicrobial activity is demonstrated by the results of the disk-test (table 3), of the minimal inhibition concentration (MIC, table 4) and the suspension and area disinfecting test following the methods of the DGHM (tables 5 and 6). It may be shown, that the N,O-acetals have both germistatic activity mainly versus Staphylococcus aureus, Bacillus subtilis, Aspergillus niger and Penicillium glaucum and germicidal activity versus the gram-negative testgerms especially Pseudomonas aeruginosa.