[Actinomycin D: toxic effects with special reference to hepatic injury].

Abstract

The action and toxic effects of Actinomycin D are discussed. Emphasized is the appearance of hepatic disfunction, that develops especially when the drug is applied during the first six months after hepatic irradiation. Two children with malignant tumor are demonstrated. In both a temporary hepatic lesion appeared after treatment with Actinomycin D.