Efectividad y seguridad de la combinación escina/procianidina en la insuficiencia venosa crónica

Fernando J. Calleja Cabrerizo , Pedro Aranda Granados , Antonio J. García Ruiz
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Abstract

Introduction

Chronic venous insufficiency is a disease that affects 20-30% of the adult population, reaching 50% in the population over 50 years. The lifestyle, hours in standing, diet and genetic factors improve the development of symptoms such as heaviness, pain or swelling of the lower limbs, as well as varicose veins.

Objective

To demonstrate the beneficial effects of the escine + procyanidine association in patients with chronic venous insufficiency assessing the changes in the patients treated by quality of life questionnaires and determining the safety.

Methodology

Prospective and longitudinal study in patients diagnosed with chronic venous insufficiency. Patients were randomly in 2 groups, usual care and the escine + procyanidine complex.

To measure results, the questionnaires SF-36v2 and VEINES-QOL/SYM were used, comparing the beginning with the end of the study. In order to measure the clinical relevance, the index denominated “d” of Cohen was calculated and used. The analysis was made by intention to treat.

Results and conclusions

In the escine + procyanidine complex patients the VEINES-SYM questionnaire indicated a significant improvement in the parameters “swollen legs”, “night cramps”, “heat/burning” and “restless legs” with respect to the Usual Care group.

Results

showed that the escine + procyanidine complex is safe, no significant differences were detected compared to the usual care group.

埃斯霉素/原花青素联合治疗慢性静脉功能不全的有效性和安全性
慢性静脉功能不全是一种影响20-30%成年人的疾病,在50岁以上人群中达到50%。生活方式、站立时间、饮食和遗传因素会改善症状的发展,如下肢的沉重、疼痛或肿胀,以及静脉曲张。目的探讨escine +原花青素联合治疗慢性静脉功能不全患者的有益作用,通过生活质量问卷评估患者治疗后的变化,确定其安全性。方法对诊断为慢性静脉功能不全的患者进行前瞻性和纵向研究。患者随机分为常规治疗组和叶青素+原花青素复合物治疗组。为了测量结果,使用问卷SF-36v2和VEINES-QOL/SYM,比较研究开始和结束时的情况。为了衡量临床相关性,我们计算并使用Cohen的“d”指数。分析的目的是治疗。结果与结论在叶青素+原花青素复合物患者中,VEINES-SYM问卷显示,与常规护理组相比,叶青素+原花青素复合物患者在“腿肿”、“夜间痉挛”、“热/灼烧”和“不宁腿”等参数均有显著改善。结果表明,叶香碱+原花青碱复合物是安全的,与常规护理组比较无显著差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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