Effect of hyperthermia alone and in combination with 60Co radiation on the growth of B16 melanoma in mice.

Abstract

B16 melanoma was grown in the tail of B6D2F1/BOM mice. Procedures for simultaneous local 60Co irradiation and heat treatment are described. A dose of 4 Gy had no effect on tumour growth; heat treatment at 41.5 degrees C for 200 min had a minor effect, while the combined treatment caused a marked delay in tumor growth. Heat treatment of tumours in the thigh at 41.5 degrees C for 2 hours did not influence the frequency of lung metastases.