Distribution of Type Specific Human Papilloma Virus (HPV) DNA among women of cervical cancer in a tertiary level hospital

Abstracts of the papers presented at 10th National Conference of Asia Oceania Research Organisation on Genital Infections and Neoplasia, India Pub Date : 2021-12-05 DOI:10.7869/aogin3

Gopa Kundu

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Abstract

Background: Infection with high-risk human papilloma virus (HPV) has been recognised as a causal factor for development of cervical pre-cancerous and cancerous lesions. So far more than 150 types of HPV are identified. Their distribution varies from country to country, also from region to region. Background knowledge about the distribution of HPV genotypes in invasive cervical cancer is crucial to guide the introduction of prophylactic vaccines. Objective: The study was aimed to assess the distribution of type specific human papilloma Virus DNA among cervical cancer patients. Methods: The study was a cross sectional, observational and single centred one. It was carried out in the department of gynaecological oncology, of Bangabandhu Sheikh Mujib Medical University (BSMMU). Purposive sampling was done according to the availability of patients. Results: HPV type 16 was detected in 35 cases (76.1%) followed by type 18 in 4 (8.7%) cases of cervical carcinoma. HPV 39, 56 and 68 were also detected, each was in 1 case (2.2 %). It was to be also found that 1 co-infection (2.2%) with HPV 33+35. HPV 16 was detected in 79.4 % of squamous cell carcinoma and in 70.0% of adenocarcinomas. HPV 18 was detected in 5.9 % of squamous cell carcinoma and 20.0% of adenocarcinomas. HPV 39 was detected in one case of small cell carcinoma (100.0%). One case of HPV 68 (2.9%) and one coinfection with HPV 33+35 (2.9 %) were found in squamous cell carcinoma. One case of HPV 56 (10.0%) was detected in adenocarcinoma of cervix. HPV DNA was not found in 3 cases of squamous cell carcinoma of cervix. Conclusion: The distribution of HPV infection among Bangladesh women is similar to other regions of Asia. However, type specific patterns are different. The study findings will guide the formulation of HPV vaccination policies in Bangladesh, impact of vaccination programmes, to predict the efficacy of cost effective prophylactic vaccine, introduction of newer generation vaccine and finally prevention of cervical carcinoma in the country. Bangladesh Med Res Counc Bull 2022; 48(1): 48-55

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人乳头瘤病毒(HPV) DNA在某三级医院宫颈癌妇女中的分布

背景:感染高危人乳头瘤病毒(HPV)已被认为是宫颈癌前病变和癌性病变发展的一个原因。到目前为止，已经发现了150多种HPV。它们的分布因国家和地区而异。了解浸润性宫颈癌中HPV基因型分布的背景知识对于指导预防性疫苗的引入至关重要。目的:探讨人乳头瘤病毒DNA在宫颈癌患者中的分布。方法:采用横断面、观察性、单中心研究。检查是在Bangabandhu Sheikh Mujib医科大学妇科肿瘤科进行的。根据病人的可用性进行有目的的抽样。结果:宫颈癌检出HPV 16型35例(76.1%)，18型4例(8.7%)。HPV 39、56、68各1例(2.2%)。HPV 33+35合并感染1例(2.2%)。HPV 16在鳞状细胞癌和腺癌中检出率分别为79.4%和70.0%。HPV 18在5.9%的鳞状细胞癌和20.0%的腺癌中检出。1例小细胞癌检出HPV 39(100.0%)。在鳞状细胞癌中发现1例HPV 68(2.9%)和1例HPV 33+35(2.9%)合并感染。宫颈腺癌检出1例HPV 56(10.0%)。3例宫颈鳞状细胞癌未检出HPV DNA。结论:孟加拉国妇女HPV感染的分布与亚洲其他地区相似。但是，类型特定的模式是不同的。研究结果将指导孟加拉国HPV疫苗接种政策的制定、疫苗接种规划的影响、预测具有成本效益的预防性疫苗的功效、引进新一代疫苗以及最终在该国预防宫颈癌。孟加拉国地中海理事会2022年公报;(1): 48 48-55

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Abstracts of the papers presented at 10th National Conference of Asia Oceania Research Organisation on Genital Infections and Neoplasia, India

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