A Case of Necrotizing Fasciitis due to Group G Streptococcus with Amputation Avoided of the Affected Limb

K. Hirayama, T. Kuroshima, M. Okada, M. Nakayama, E. Miyano, M. Sugawara, K. Hayashi, Y. Horikoshi, D. Kawata, S akauji, N. Kokita, Yamamoto Ai, S. Fujita
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Abstract

Group G Streptococcus (GGS) causes toxic shock syndrome. Its incidence has been increasing in the elderly in recent years. The case is a female patient in her 60s, with rheumatoid arthritis, who developed necrotizing fasciitis in her right thigh. We administered antibacterial agents and debridement frequently at an early stage, followed by aggressive high-protein enteral nutrition and multidisciplinary treatment. During the course of treatment, the patient’s general condition temporarily deteriorated because of fecal contamination. We considered amputation of the lower limb and implantation of a stoma, but finally succeeded in preserving the limb by performing two skin grafts. The patient was able to walk and was discharged on day 66. GGS infection is a risk factor for elderly patients with underlying diseases such as malignancy or immunocompromised states. When necrotizing fasciitis due to fulminant streptococcal infection develops in a proximal limb, amputation of the limb is often necessary to save the patient’s life. In this case, a fulminant GGS infection developed in an immunocompromised patient with active rheumatoid arthritis. Although the risk of limb amputation was high, multidisciplinary treatment enabled functional preservation of the affected limb.
G群链球菌致坏死性筋膜炎1例,患肢避免截肢
G群链球菌(GGS)引起中毒性休克综合征。近年来,其在老年人中的发病率呈上升趋势。该病例是一名60多岁的女性患者,患有风湿性关节炎,右大腿出现坏死性筋膜炎。我们在早期经常使用抗菌药物和清创,然后进行积极的高蛋白肠内营养和多学科治疗。在治疗过程中,由于粪便污染,患者的一般情况暂时恶化。我们考虑截肢下肢和植入一个造口,但最终成功地保留肢体进行两次皮肤移植。患者能够行走,并于第66天出院。对于患有恶性肿瘤或免疫功能低下等基础疾病的老年患者,GGS感染是一个危险因素。当肢体近端发生由暴发性链球菌感染引起的坏死性筋膜炎时,通常需要截肢以挽救患者的生命。在这种情况下,暴发性GGS感染发展在免疫功能低下的患者活动性类风湿关节炎。虽然肢体截肢的风险很高,但多学科治疗使受影响肢体的功能得以保留。
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