Nephrolithiasis and the risk of myocardial infarction and stroke.

А.Е. Alfimov, I. Shaderkin, G. Lebedev, O. Leontiev
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Abstract

Introduction. The article discusses the results of studies and meta-analyses that have studied the risks of coronary heart disease (CHD), myocardial infarction (MI) and stroke in patients with urinary stone disease (USD). The purpose of this review is to critically analyze the available studies on the association of USD with CHD and stroke, as well as to evaluate USD among other cardiovascular disease (CVD) risk factors and to assess the role of USD metaphylaxis in reducing this risk. Materials and methods. The authors conducted a search in international and domestic specialized databases of scientific publications, 657 publications were found. For this review, 75 articles were selected that were published no later than April 1, 2021. Results. Despite conflicting research results and high statistical heterogeneity, all meta-analyses have shown that patients with USD have an increased risk of coronary artery disease, MI, and stroke by about 20-40%. In comparison with other risk factors for CVD, USD represents a moderate risk, which dictates not only the need to identify and correct «high» risk factors in patients with USD, but also the need for effective metaphylaxis. There are no studies to support the efficacy of USD metaphylaxis in reducing the risk of CVD. However, it can be assumed that effective metaphylaxis, especially in young patients, using remote technologies, will not only reduce the risk of urolithiasis recurrence, but also help correct metabolic disorders that trigger pathophysiological processes common with CVD. The possibility that simple and inexpensive interventions that reduce the risk of recurrent urolithiasis may also reduce the risk of MI and stroke, the most common cause of death and disability, warrants further study. Conclusions. To increase the effectiveness of USD metaphylaxis, it is possible to use remote monitoring with automatic data processing and regular feedback.
肾结石与心肌梗死和中风的风险。
介绍。本文讨论了研究泌尿系结石病(USD)患者冠心病(CHD)、心肌梗死(MI)和卒中风险的研究和荟萃分析的结果。本综述的目的是批判性地分析USD与冠心病和卒中之间关系的现有研究,以及评估USD与其他心血管疾病(CVD)危险因素之间的关系,并评估USD过敏反应在降低这种风险方面的作用。材料和方法。作者检索了国际国内专业科学出版物数据库,共检索到657篇论文。本次综述选取了不迟于2021年4月1日发表的75篇文章。结果。尽管有相互矛盾的研究结果和较高的统计异质性,但所有的荟萃分析都表明,USD患者发生冠状动脉疾病、心肌梗死和中风的风险增加了约20-40%。与CVD的其他危险因素相比,USD代表着中等风险,这不仅表明需要识别和纠正USD患者的“高”危险因素,而且还需要有效的过敏反应。目前还没有研究支持美金过敏反应在降低心血管疾病风险方面的疗效。然而,可以假设有效的过敏反应,特别是在年轻患者中,使用远程技术,不仅可以降低尿石症复发的风险,还可以帮助纠正引发CVD常见病理生理过程的代谢紊乱。降低尿石症复发风险的简单而廉价的干预措施也可能降低心肌梗死和中风(最常见的死亡和残疾原因)的风险,这一可能性值得进一步研究。结论。为了提高美元过敏反应的有效性,可以使用远程监测与自动数据处理和定期反馈。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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