Plant-Derived Secondary Metabolites as Potential Mediators against COVID-19: A Review

Prithvi Academic Journal Pub Date : 1900-01-01 DOI:10.3126/paj.v3i1.31282

Lekhanath Khanal, Yuba Raj Pokharel, K. Sharma, S. K. Kalauni

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Abstract

The current pandemic of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has envisioned a global health concern The scientists and physicians around the world have been racing to understand the pathophysiology and possible treatment régimes to discover an effective therapeutic resolution against the disease Different secondary metabolites from plants exhibit substantial biological assets including antiviral activity These compounds may be used against the infections of coronavirus The research papers, reviews, and preprints were searched from the PubMed database using keywords like severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome (MERS), and traditional herbal medicine against COVID-19 The review focuses on those natural products which exhibited optimistic results against SARS-COV and SARS-CoV-2 in virtual as well as physical in vitro and in vivo tests It summarizes the epidemiological characters, pathogenesis, structure, and targeting strategies of the virus The compounds like lycorine, psoralidin, quercetin, glycyrrhizin, baicalin, caffeic acid, etc could be the leads for the drug development against COVID-19

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植物源次生代谢物作为抗COVID-19潜在介质的研究进展

当前由严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2)引起的COVID-19大流行已引起全球健康关注，世界各地的科学家和医生一直在竞相了解病理生理学和可能的治疗方法，以发现有效的治疗方案，以发现针对该疾病的不同的植物次生代谢物具有包括抗病毒活性在内的大量生物资产以SARS-CoV (SARS-CoV)、中东呼吸综合征(MERS)、传统中草药等为关键词，从PubMed数据库中检索抗新冠肺炎的相关研究论文、综述和预印本，重点对在虚拟和实体体外和体内试验中对SARS-CoV和SARS-CoV-2表现出乐观效果的天然产物进行综述。其中，石蒜碱、补骨脂素、槲皮素、甘草酸、黄芩苷、咖啡酸等化合物可能成为抗新冠病毒药物开发的先导

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Prithvi Academic Journal

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