Hepatoprotective effect of protein extract of the Potamogeton perfoliatus L. against carbon-tetrachloride-induced hepatic injury in mice

Abstract

This article demonstrates the hepatoprotective action of the protein extract of the aquatic plant Potamogeton perfoliatus L. based on the histopathologic changes in the liver of mice with CCl4-induced liver damage. Using the chromatography, 4 fractions of the protein extract were obtained. It has been suggested that a fourth fraction corresponding to low molecular weight protein should most likely exhibit hepatoprotective properties. SDS-PAGE of P. perfoliatus L. revealed a protein with molecular weight of 21 kDa corresponding to the fourth peak of a chromatogram.