Challenges in the Treatment of Oligometastatic Non-small Cell Lung Cancer

M. Vrankar
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引用次数: 2

Abstract

Since 1995, when the concept of oligometastatic non-small cell lung cancer was first described, no high-level evidence has been introduced for management of those patients subset. Data from retrospective reports and analysis and from every-day clinical practice revealed that some of the non-small cell lung cancer patients with a few metastases could benefit significantly with local radical treatment approach of primary and metastatic lesions. Recent advances in modern local treatment approaches with minimally invasive surgery and stereotactic radiotherapy, as well as introduction of immunotherapy, open new field of interest for personalized treatment of limited metastatic non-small cell lung cancer. In this report, we are summarizing limited data of case reports, retrospective studies and few randomized studies of patients with oligometastatic non-small cell lung cancer and discuss challenges of treatment in the era of molecular targeted therapy and immunotherapy.
少转移性非小细胞肺癌治疗的挑战
自1995年以来,当少转移性非小细胞肺癌的概念首次被描述时,没有引入高水平的证据来管理这些患者亚群。回顾性报告和分析以及日常临床实践的数据显示,部分转移灶较少的非小细胞肺癌患者采用局部根治性治疗原发灶和转移灶均可显著获益。现代局部治疗方法的最新进展,包括微创手术和立体定向放疗,以及免疫疗法的引入,为有限转移性非小细胞肺癌的个性化治疗开辟了新的研究领域。在本报告中,我们总结了有限的病例报告、回顾性研究和少数随机研究的非小细胞肺癌患者的数据,并讨论了分子靶向治疗和免疫治疗时代治疗的挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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