IDDF2021-ABS-0202 Crotonylation of SEPT2 protein predicts poor prognosis in hepatocellular carcinoma

Abstract

IDDF2021-ABS-0205 Figure 1 Abstracts A8 Gut 2021;70(Suppl 2):A1–A150 on D ecem er 2, 2021 by gest. P rocted by coright. http/gut.bm jcom / G t: frst pulished as 10.113utjnl-2021-ID D F 11 on 2 S etem er 221. D ow nladed fom FBG (*P<0.05, **P<0.01, ***P< 0.001)) (IDDF2021-ABS0205 Figure 1f. Akkermansia viable improved liver steatosis; serum levels of HOMA-IR (**P<0.01, ***P< 0.001)). The a diversity of intestinal microflora in HFD group was lower than that in CD group. Compared with HFD group, The a diversity of intestinal microflora in HFD+LAKK group and HFD+ Supernatant group were increased (IDDF2021-ABS0205 Figure 1g. Akkermansia viable improved liver steatosis; Alpha diversity). PCoA analysis showed that there were differences among groups (IDDF2021-ABS-0205 Figure 1h. Akkermansia viable improved liver steatosis; PCoA analyses). Compared with CD group, the F/B ratio increased was increased in HFD group but decreased in HFD+LAKK group and the HFD+ Supernatant group (IDDF2021-ABS-0205 Figure 1i. Akkermansia viable improved liver steatosis; Phylum level of gut microbiota composition). The bacteria abundance of HFD group and HFD+ PAKK group was similar. HFD +LAKK group and HFD+ Supernatant group had similar bacteria abundances, such as the increasing of Akkermansia, Alloprevotella, and Roseburia (IDDF2021-ABS-0205 Figure 1j. Akkermansia viable improved liver steatosis; Bacterial heatmap at genus level. CD, control diet; HFD, high-fat diet; LAKK, Akkermansia viable; PAKK, pasteurized Akkermansia). Conclusions Akkermansia viable, pasteurized Akkermansia and supernatant improve glucose metabolism and insulin resistance, whereas Akkermansia viable and supernatant improve gut microbiota. Only Akkermansia viable can improve liver steatosis and lipid metabolism. Akkermansia viable effectively increases probiotics. Chuangyu Cao and Diwen Shou contributed equally to this work. Clinical Gastroenterology IDDF2021-ABS-0033 PROTECTIVE EFFECTS OF FEMALE REPRODUCTIVE FACTORS ON GASTRIC SIGNET RING CELL CARCINOMA Yang Li*. National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, China 10.1136/gutjnl-2021-IDDF.12 Background The overall incidence of gastric cancer is higher in males than in females worldwide. However, gastric signet ring cell carcinoma (GSRC) is more frequently observed in younger female patients. Limited studies focused on sex-specific differences in GSRC have been reported. Gastric cancer shows a male predominance that might be explained by protective effects from estrogens in females. The aim of this study was to analyze clinicopathological differences between sex groups to reveal sex disparities in GSRC. Methods We reviewed medical records for and surveying reproductive factors, to 1,431 patients who get treatment for GSRC at Cancer Hospital, Chinese Academy of Medical Sciences from January 2011 to December 2018. Clinicopathological characteristics were compared between females and males. The mortality risks of GSRC were compared between males and females’ subgroups, consist of premenopausal women, and postmenopausal women. Results Of 1,431 patients, 935 and 496 patients were divided into male and female groups separately. Further, the female group was divided into menstrual female group (181 patients) and menopausal female group (315 patients). 5-year OS was observed for male, menstrual female group and menopausal female group (65.6% vs. 76.5% vs. 65%, P<0.01, separately). In the multivariate analysis, lower BMI (HR= 1.24, 95% CI:1.02, 1.51), neoadjuvant chemotherapy (HR=2.34, 95% CI:1.79, 3.04), lymphovascular invasion (HR=1.39, 95% CI:1.02, 1.90) were recognized as risk factors. The menstrual female was found as a protective factor (HR=0.58, 95%CI: 0.42,0.82).(IDDF2021-ABS-0033 Figure 1. Overall survival among male, menstrual female and menopausal female groups) Conclusions Female patients of GSRC were younger than males at diagnosis. The mortality risks of premenopausal female patients are much lower than males. The contribution of this study has been to confirm that the female reproductive factors may provide protective effects in GSRC patients. It would be interesting to assess the effects of female reproductive factors to investigate a new treatment for a group of selected GSRC patients. IDDF2021-ABS-0122 NO ASSOCIATION BETWEEN PROTONPUMP INHIBITOR USE AND ADVERSE CLINICAL OUTCOMES OF COVID-19: A TERRITORY-WIDE COHORT STUDY OF 8,675 PATIENTS Terry Cheuk-Fung Yip*, Francis Ka-Leung Chan, Grace Chung-Yan Lui, Vincent WaiSun Wong, Henry Lik-Yuen Chan, Sunny Hei-Wong, Joyce Wing-Yan Mak, SiewChien Ng, David Shu-Cheong Hui, Grace Lai-Hung Wong. Department of Medicine and Therapeutics, Medical Data Analytics Centre (MDAC), Institute of Digestive Disease, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong; Department of Medicine and Therapeutics, Medical Data Analytics Centre (MDAC), Stanley Ho Centre for Emerging Infectious Diseases, Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong; Medical Data Analytics Centre (MDAC), Faculty of Medicine, The Chinese University of Hong Kong; Department of Internal Medicine, Union Hospital, Hong Kong 10.1136/gutjnl-2021-IDDF.13 Background Evidence regarding the use of proton-pump inhibitors (PPIs) in COVID-19 patients remains elusive. We examined the impact of PPI use on clinical outcomes of COVID-19 patients in a territory-wide cohort. Methods We performed a retrospective cohort study using data from an electronic healthcare database managed by the Hospital Authority, Hong Kong. COVID-19 patients diagnosed virologically between 23 January 2020 and 1 January Abstract IDDF2021-ABS-0033 Figure 1 Abstracts Gut 2021;70(Suppl 2):A1–A150 A9 on D ecem er 2, 2021 by gest. P rocted by coright. http/gut.bm jcom / G t: frst pulished as 10.113utjnl-2021-ID D F 11 on 2 S etem er 221. D ow nladed fom