DESIGN OF B23 CIRCULAR DICHROISM BEAMLINE AT DIAMOND LIGHT SOURCE

Abstract

Synchrotron circular dichroism (CD) is already a valuable technique for studies of protein folding, conformational changes and enzyme mechanisms, as well as secondary structure determination. Exciting new potential applications exist in protein folding, protein complex formation for Proteomics, and ligand/drug screening for Functional Genomics. With the 3 GeV synchrotron of Diamond Light Source we can collimate a very small size light beam (about 2 mm (H) × 1 mm (V)) with high photon flux (estimated 8 × 1013 (ph/s/0.1%bw) at 6 eV and 300 mA). The small beam size will enable the measurement of smaller sample volumes that previously has not been possible.