Incorporating Compatible Pairs in Kidney Exchange: A Dynamic Weighted Matching Model

Zhuoshu Li, Kelsey Lieberman, William Macke, Sofia Carrillo, Chien-Ju Ho, J. Wellen, Sanmay Das
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引用次数: 12

Abstract

Kidney exchange has been studied extensively from the perspective of market design, and a significant focus has been on better algorithms for finding chains and cycles to increase the number of possible matches. A more dramatic benefit could come from incorporating compatible pairs into the mechanism, but this possibility has been relatively understudied. In order to incentivize a compatible pair to participate in exchange, they must be offered a higher quality match for the recipient that can be performed without adding extra waiting time. In this paper, we make two main contributions to the study of incorporating compatible pairs in exchanges. First, we leverage the recently proposed Living Donor Kidney Profile Index (LKDPI) to measure match quality, and develop a novel simulator (based on data from a major transplant center) for the joint distribution of compatibility and quality across pairs. This simulator allows us to study the benefits of including compatible pairs under different models and assumptions. Second, we introduce a hybrid online/batch matching model with impatient (compatible) and patient (incompatible) pairs to capture the need for immediacy. We introduce new algorithms for matching in this model, including one based on online primal-dual techniques. Overall, our results indicate great potential in terms of both increased numbers of transplants of incompatible pairs (almost doubling the number transplanted) as well as improved match quality for recipients in compatible pairs (increasing expected graft survival by between 1 and 2 years). The results are also promising for hard-to-match subpopulations, including blood group O recipients.
在肾脏交换中纳入相容配对:一个动态加权匹配模型
从市场设计的角度对肾脏交换进行了广泛的研究,其中一个重要的重点是寻找链和周期以增加可能匹配数量的更好算法。将相容对结合到机制中可能会带来更大的好处,但这种可能性的研究相对不足。为了激励兼容的配对参与交换,必须为接收者提供更高质量的匹配,而无需增加额外的等待时间。在本文中,我们对在交换中纳入兼容对的研究做出了两个主要贡献。首先,我们利用最近提出的活体供体肾脏特征指数(LKDPI)来衡量匹配质量,并开发了一个新的模拟器(基于来自主要移植中心的数据),用于跨配对的相容性和质量的联合分布。这个模拟器允许我们研究在不同模型和假设下包含兼容对的好处。其次,我们引入了一个混合在线/批量匹配模型,其中包括不耐烦(兼容)和耐心(不兼容)对,以捕捉对即时性的需求。我们引入了新的匹配算法,包括一种基于在线原始对偶技术的匹配算法。总的来说,我们的研究结果表明,在增加不相容配对的移植数量(几乎是移植数量的两倍)以及改善相容配对受体的匹配质量(增加1至2年的预期移植物存活)方面,我们的研究结果显示了巨大的潜力。这一结果对于包括O型血受体在内的难以匹配的亚群也很有希望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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