In vitro interactions of titanium bioalloys with human cells and physiological fluids

M. Popa, E. Vasilescu, P. Drob, D. Iordăchescu, A. Cîmpean, D. Ionita, C. Vasilescu
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引用次数: 1

Abstract

Studies concerning the long-term electrochemical behavior in artificial saliva and interactions with fibroblasts of Ti-45.5Ni bioalloy are performed in this paper. Titanium and its Ti-45.5Ni alloy revealed a typical passive metal behavior in Tani&Zucchi (of pH=2.5 and 7) and Fusayama (pH=5.5) artificial saliva. Breakdown (pitting) potential has electropositive values that can not be reached in oral cavity. Corrosion potentials for Ti-45.5Ni alloy in Carter-Brugirard saliva presented more electronegative values than titanium, but no form of local corrosion was registered during 4000 exposure hours. Corrosion potential gradients simulated for saliva composition non-uniformity have low values, showing very good corrosion resistance. Human embryonic fibroblasts rapidly adhered (72% cells in 48 hours) on Ti-45.5Ni alloy surface. Cell proliferation is considerable in the first 48 hours of culture. Slight cytotoxic effects specially developed after 72 incubation hours
钛生物合金与人体细胞和生理液体的体外相互作用
本文研究了Ti-45.5Ni生物合金在人工唾液中的长期电化学行为及其与成纤维细胞的相互作用。钛及其Ti-45.5Ni合金在Tani&Zucchi (pH= 2.5和7)和Fusayama (pH=5.5)人工唾液中表现出典型的钝化金属行为。击穿(点蚀)电位具有在口腔内无法达到的正电值。Ti-45.5Ni合金在Carter-Brugirard唾液中的腐蚀电位比钛具有更大的电负性,但在4000小时内没有发现任何形式的局部腐蚀。模拟的唾液成分不均匀性腐蚀电位梯度值较低,具有很好的耐蚀性。人胚胎成纤维细胞在Ti-45.5Ni合金表面快速粘附,48h内达到72%。细胞增殖在培养的前48小时内是相当可观的。经过72小时的孵育,产生轻微的细胞毒性作用
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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