CANDIDA SPECIES IN THE GENITAL TRACT OF WOMEN ATTENDING A UNIVERSITY HOSPITAL FOR GYNECOLOGICAL INTERVENTIONS

Thais Chimati Felix, R. Menezes, Marília Cristina Berardi, D. Röder, R. Pedroso
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引用次数: 1

Abstract

Introduction: Vulvovaginal candidiasis occurs in about 75% of all women during reproductive age, and around half of those will have at least one recurrent episode. Objectives: To evaluate the occurrence of Candida species in the genital tract of women attending a clinic of Gynecology and Obstetrics at the University Hospital for gynecological interventions, related to signs and symptoms of infection and also to evaluate the susceptibility to antifungal agents of the Candida isolates. Methods and materials: Samples of vaginal secretions were taken of 128 women during gynecological and colposcopic examination, through sterile swab, to carry out culture for fungi. Susceptibility tests were performed for fluconazole, itraconazole, voriconazole, nystatin and amphotericin B. Results: Twenty (15.6%) patients had positive culture for yeasts identified as: C. albicans (57.1%), C. glabrata (19%), C. parapsilosis complex (4.8%), C. lipolytica (4.8%), Trichosporon sp (9.5%), and Rhodotorula sp (4.8%). Ninety women (70.3%) reported no symptoms and 38 (29.6%) were symptomatic. The most frequent complaints were: discharge, vulval itching, and dyspareunia. All isolates were susceptible to the antifungal agents tested, except for some isolates of C. parapsilosis complex, which showed in vitro resistance to itraconazole. Conclusions: Although Candida species were isolated in only some of the women, C. albicans was the most common species. The more frequent complaints were discharge and vulvar itching. Most of the isolates were susceptible to the antifungals tested.
念珠菌种在生殖道的妇女参加大学医院妇科干预
导读:大约75%的育龄妇女患有外阴阴道念珠菌病,其中约一半的妇女至少有一次复发。目的:评估在大学医院妇产科门诊接受妇科干预的妇女生殖道中念珠菌种类的发生情况,与感染的体征和症状有关,并评估念珠菌分离株对抗真菌药物的敏感性。方法与材料:对128例妇科及阴道镜检查妇女阴道分泌物标本,采用无菌拭子法进行真菌培养。对氟康唑、伊曲康唑、voriconazole、制霉菌素和两性霉素b进行药敏试验。结果:20例(15.6%)患者的酵母菌培养阳性,鉴定为:白色念珠菌(57.1%)、光秃念珠菌(19%)、副枯草念珠菌复合体(4.8%)、多脂念珠菌(4.8%)、Trichosporon sp(9.5%)、Rhodotorula sp(4.8%)。90名妇女(70.3%)报告无症状,38名妇女(29.6%)有症状。最常见的主诉是:分泌物、外阴瘙痒和性交困难。所有菌株均对抗真菌药物敏感,但部分菌株对伊曲康唑有耐药性。结论:虽然在部分女性中分离到念珠菌,但白色念珠菌是最常见的菌种。更常见的主诉是分泌物和外阴瘙痒。大多数分离株对所检测的抗真菌药物敏感。
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