Toxic Effects of Nickel Nanoparticles in a Subacute Oral Administration to Rats

Abstract

: The toxic effects have been evaluated of Nickel nanoparticles (NiNPs) at their 92-day oral administration to male Wistar rats at doses of 0.1; 1 and 10 mg/kg body weight. An increase in glycemia, triglyceride, LDL, total protein, and its globulin fraction levels were noticed in NiNPs exposed rats. NiNPs caused a decrease in the reserves of reduced liver glutathione and excretion of selenium in the urine, an increase in serum levels of cytokines IL-1β, IL-2, IL-6, IL-12p70, TNF-α, and INF-γ with simultaneous decrease in IL-17A as well as increased fibrosis-marking genes and Tp53 expression.