When Mosquito Bite Allergy with Epstein-Barr Virus Infection Requires Hematopoietic Stem Cell Transplant

Abstract

Introduction: Epstein-Barr virus (EBV) can present with varied clinical patterns. In acute infection, common symptoms include fever, malaise, and lymphadenopathy. However, chronic EBV can also cause lymphoproliferative disorders and malignancy. Case Description: A 5-year-old boy with history of nasal allergies and asthma presented with fever to 104 degrees Fahrenheit, exudative tonsillitis, oral sores, and moderate cervical lymphadenopathy. Rapid strep test was negative. One month later, he developed fever with severe local reactions to mosquito bites, each with >5 cm of erythema, induration, and bulla that ulcerated after rupture (Figures1&2). Afterward, he continued to have …