Use of proton pump inhibitors in patients with COVID-19 infection: Are we doing more harm than good?

Abstract

Purpose: The purpose of this paper was to highlight the use of proton pump inhibitors (PPIs) in the supportive treatment of COVID-19 infection and the potential effects associated with their use. Methodology: This was a theoretical paper. Findings: COVID-19 pandemic has had a profound negative impact worldwide on the economic and healthcare machinery. PPIs are important drugs used as supportive therapy for various medical conditions like heart-burn and acid peptic disease. There is an on-going deliberation regarding the probable useful versus deleterious effects of PPI use in patients with COVID-19 infection. Some authorities believe in their usefulness as anti-oxidant and anti-inflammatory agents, while others prove with evidence the potential harm caused by their use in terms of increased vulnerability to infections.  Recommendation: Given their possible side-effects, prudent usage of PPI therapy is warranted in patients with active COVID-19 infection.   Keywords: Pandemic, COVID-19, SARS-CoV-2, proton pump inhibitors