Integration of Co-expression Networks for Gene Clustering

Abstract

Simultaneous overexpression or underexpression of multiplegenes, used in various forms as probes in the highthroughput microarray experiments, facilitates the identification of their underlying functional proximity. This kind of functional associativity (or conversely the separability) between the genes can be represented roficiently using coexpression networks. The extensive repository of diversified microarray data encounters a recent problem of multiexperimental data integration for the aforesaid purpose. This paper highlights a novel integration method of gene coexpression networks, based on the search for their consensus network, derived from diverse microarray experimental data for the purpose of clustering. The proposed methodology avoids the bias arising from missing value estimation. The method has been applied on microarray datasets arising from different category of experiments to integrate them. The consensus network, thus produced, reflects robustness based on biological validation.