1014 Complement C3 deficiency increases the anti-tumor immunity of NK cells and controls tumor growth

Abstract

wild-type NK cells. NK cells isolated from tumor-bearing -/- mice showed cytotoxic activity to the NK cells increased secretion of pro-inflammatory cytokines as GM-CSF and IFN-g when with IL-2, IL-15, IL-18 compared to NK cells. Depleting NK cells in -/- mice with anti-NK1.1 mAb significantly prevented the reduction of growth as compared to isotype control IgG mAb.