Tumor Motion Prediction and Tracking in Adaptive Radiotherapy

Abstract

Respiratory and cardiac motions induce displacement and deformation of the tumor-volume in various internal organs. To accommodate this undesired movement and other errors, physicians incorporate a large margin around the tumor to delineate Planning Target Volume (PTV), so that the Clinical Target Volume (CTV) receives the prescribed radiation dose under any scenario. Consequently, a large volume of healthy tissue is irradiated and sometimes it is difficult to spare critical organs adjacent to the tumor. In this study we have proposed a novel approach to 4D Active Tracking and Dynamic Delivery (ATDD) together with tumor motion prediction. Proposed algorithm can predict tumor position and the robotic system can continuously track the tumor during radiation dose delivery, so that a precise dose is given to a moving target while reducing dose to nearby critical organs for improved patient treatment outcome. The efficacy of the proposed method has been investigated by extensive computer simulation. The results have been presented in this article.